| The SAS System |
| Model Information | |
|---|---|
| Data Set | WORK.DAT_TWISK_L |
| Response Variable | CHG |
| Response Distribution | Gaussian |
| Link Function | Identity |
| Variance Function | Default |
| Variance Matrix Blocked By | USUBJID |
| Estimation Technique | Restricted Maximum Likelihood |
| Degrees of Freedom Method | Satterthwaite |
| Class Level Information | ||
|---|---|---|
| Class | Levels | Values |
| USUBJID | 139 | not printed |
| TRT01P | 2 | TRT CNT |
| Number of Observations Read | 304 |
|---|---|
| Number of Observations Used | 249 |
| Dimensions | |
|---|---|
| R-side Cov. Parameters | 3 |
| Columns in X | 4 |
| Columns in Z per Subject | 0 |
| Subjects (Blocks in V) | 139 |
| Max Obs per Subject | 2 |
| Optimization Information | |
|---|---|
| Optimization Technique | Dual Quasi-Newton |
| Parameters in Optimization | 3 |
| Lower Boundaries | 2 |
| Upper Boundaries | 0 |
| Fixed Effects | Profiled |
| Starting From | Data |
| Iteration History | |||||
|---|---|---|---|---|---|
| Iteration | Restarts | Evaluations | Objective Function |
Change | Max Gradient |
| 0 | 0 | 4 | 1858.4198529 | . | 0.13064 |
| 1 | 0 | 4 | 1858.1038377 | 0.31601516 | 0.031162 |
| 2 | 0 | 4 | 1858.0684343 | 0.03540342 | 0.025972 |
| 3 | 0 | 4 | 1858.0505179 | 0.01791644 | 0.00536 |
| 4 | 0 | 2 | 1858.0496086 | 0.00090922 | 0.001768 |
| 5 | 0 | 2 | 1858.0494783 | 0.00013036 | 0.00062 |
| 6 | 0 | 3 | 1858.0494403 | 0.00003801 | 0.000152 |
| 7 | 0 | 3 | 1858.0494397 | 0.00000059 | 4.361E-7 |
| Convergence criterion (GCONV=1E-8) satisfied. |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 1858.05 |
| AIC (smaller is better) | 1864.05 |
| AICC (smaller is better) | 1864.15 |
| BIC (smaller is better) | 1872.85 |
| CAIC (smaller is better) | 1875.85 |
| HQIC (smaller is better) | 1867.63 |
| Generalized Chi-Square | 246.00 |
| Gener. Chi-Square / DF | 1.00 |
| Covariance Parameter Estimates | |||
|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error |
| UN(1,1) | USUBJID | 113.45 | 14.2886 |
| UN(2,1) | USUBJID | 43.8819 | 11.6136 |
| UN(2,2) | USUBJID | 109.96 | 14.7327 |
| Solutions for Fixed Effects | ||||||
|---|---|---|---|---|---|---|
| Effect | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| |
| Intercept | 48.5339 | 6.9123 | 122.3 | 7.02 | <.0001 | |
| TRT01P | TRT | -3.6908 | 1.5872 | 118.1 | -2.33 | 0.0218 |
| TRT01P | CNT | 0 | . | . | . | . |
| BASE | -0.3866 | 0.05226 | 122.7 | -7.40 | <.0001 | |
| Type III Tests of Fixed Effects | ||||
|---|---|---|---|---|
| Effect | Num DF | Den DF | F Value | Pr > F |
| TRT01P | 1 | 118.1 | 5.41 | 0.0218 |
| BASE | 1 | 122.7 | 54.74 | <.0001 |
| TRT01P Least Squares Means | ||||||||
|---|---|---|---|---|---|---|---|---|
| TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| TRT | -4.7527 | 1.1290 | 117 | -4.21 | <.0001 | 0.05 | -6.9885 | -2.5168 |
| CNT | -1.0618 | 1.1023 | 119.2 | -0.96 | 0.3373 | 0.05 | -3.2444 | 1.1207 |
| Differences of TRT01P Least Squares Means | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| TRT01P | _TRT01P | Estimate | Standard Error | DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| TRT | CNT | -3.6908 | 1.5872 | 118.1 | -2.33 | 0.0218 | 0.05 | -6.8340 | -0.5477 |