| The SAS System |
| Model Information | |
|---|---|
| Data Set | WORK.DAT_TWISK_L |
| Response Variable | CHG |
| Response Distribution | Gaussian |
| Link Function | Identity |
| Variance Function | Default |
| Variance Matrix Blocked By | USUBJID |
| Estimation Technique | Restricted Maximum Likelihood |
| Degrees of Freedom Method | Satterthwaite |
| Class Level Information | ||
|---|---|---|
| Class | Levels | Values |
| USUBJID | 152 | not printed |
| AVISIT | 2 | Week 24 Week 12 |
| TRT01P | 2 | TRT CNT |
| Number of Observations Read | 304 |
|---|---|
| Number of Observations Used | 249 |
| Dimensions | |
|---|---|
| R-side Cov. Parameters | 3 |
| Columns in X | 9 |
| Columns in Z per Subject | 0 |
| Subjects (Blocks in V) | 152 |
| Max Obs per Subject | 2 |
| Optimization Information | |
|---|---|
| Optimization Technique | Dual Quasi-Newton |
| Parameters in Optimization | 3 |
| Lower Boundaries | 2 |
| Upper Boundaries | 0 |
| Fixed Effects | Profiled |
| Starting From | Data |
| Iteration History | |||||
|---|---|---|---|---|---|
| Iteration | Restarts | Evaluations | Objective Function |
Change | Max Gradient |
| 0 | 0 | 4 | 1892.1440355 | . | 0.243964 |
| 1 | 0 | 6 | 1890.6384007 | 1.50563484 | 0.0733 |
| 2 | 0 | 2 | 1890.5539443 | 0.08445635 | 0.039922 |
| 3 | 0 | 4 | 1890.3442116 | 0.20973275 | 0.048689 |
| 4 | 0 | 2 | 1890.2993061 | 0.04490550 | 0.019714 |
| 5 | 0 | 2 | 1890.2830114 | 0.01629469 | 0.018611 |
| 6 | 0 | 2 | 1890.2680461 | 0.01496526 | 0.020294 |
| 7 | 0 | 3 | 1890.2590672 | 0.00897895 | 0.002623 |
| 8 | 0 | 3 | 1890.2584518 | 0.00061536 | 0.000055 |
| 9 | 0 | 3 | 1890.2584512 | 0.00000064 | 5.431E-6 |
| Convergence criterion (GCONV=1E-8) satisfied. |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 1890.26 |
| AIC (smaller is better) | 1896.26 |
| AICC (smaller is better) | 1896.36 |
| BIC (smaller is better) | 1905.33 |
| CAIC (smaller is better) | 1908.33 |
| HQIC (smaller is better) | 1899.94 |
| Generalized Chi-Square | 245.00 |
| Gener. Chi-Square / DF | 1.00 |
| Covariance Parameter Estimates | |||
|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error |
| UN(1,1) | USUBJID | 139.77 | 17.4709 |
| UN(2,1) | USUBJID | 80.8970 | 16.1971 |
| UN(2,2) | USUBJID | 153.29 | 21.0372 |
| Solutions for Fixed Effects | |||||||
|---|---|---|---|---|---|---|---|
| Effect | AVISIT | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| |
| Intercept | -0.6418 | 1.4443 | 128 | -0.44 | 0.6575 | ||
| TRT01P | TRT | -2.7392 | 2.0748 | 128 | -1.32 | 0.1891 | |
| TRT01P | CNT | 0 | . | . | . | . | |
| AVISIT | Week 24 | -2.9209 | 1.4645 | 113.2 | -1.99 | 0.0485 | |
| AVISIT | Week 12 | 0 | . | . | . | . | |
| AVISIT*TRT01P | Week 24 | TRT | 1.9225 | 2.0839 | 112.3 | 0.92 | 0.3582 |
| AVISIT*TRT01P | Week 24 | CNT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 12 | TRT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 12 | CNT | 0 | . | . | . | . |
| Type III Tests of Fixed Effects | ||||
|---|---|---|---|---|
| Effect | Num DF | Den DF | F Value | Pr > F |
| TRT01P | 1 | 115.9 | 0.88 | 0.3492 |
| AVISIT | 1 | 112.3 | 3.54 | 0.0626 |
| AVISIT*TRT01P | 1 | 112.3 | 0.85 | 0.3582 |
| AVISIT*TRT01P Least Squares Means | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| AVISIT | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Week 24 | TRT | -4.3793 | 1.5962 | 109.7 | -2.74 | 0.0071 | 0.05 | -7.5427 | -1.2159 |
| Week 24 | CNT | -3.5627 | 1.5727 | 112 | -2.27 | 0.0254 | 0.05 | -6.6788 | -0.4466 |
| Week 12 | TRT | -3.3810 | 1.4895 | 128 | -2.27 | 0.0249 | 0.05 | -6.3281 | -0.4338 |
| Week 12 | CNT | -0.6418 | 1.4443 | 128 | -0.44 | 0.6575 | 0.05 | -3.4996 | 2.2161 |
| Differences of AVISIT*TRT01P Least Squares Means | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AVISIT | TRT01P | _AVISIT | _TRT01P | Estimate | Standard Error | DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Week 24 | TRT | Week 24 | CNT | -0.8166 | 2.2408 | 110.8 | -0.36 | 0.7162 | 0.05 | -5.2570 | 3.6238 |
| Week 24 | TRT | Week 12 | TRT | -0.9983 | 1.4826 | 111.4 | -0.67 | 0.5021 | 0.05 | -3.9362 | 1.9395 |
| Week 24 | TRT | Week 12 | CNT | -3.7375 | 2.1527 | 182.9 | -1.74 | 0.0842 | 0.05 | -7.9847 | 0.5097 |
| Week 24 | CNT | Week 12 | TRT | -0.1817 | 2.1661 | 187.7 | -0.08 | 0.9332 | 0.05 | -4.4547 | 4.0913 |
| Week 24 | CNT | Week 12 | CNT | -2.9209 | 1.4645 | 113.2 | -1.99 | 0.0485 | 0.05 | -5.8222 | -0.01959 |
| Week 12 | TRT | Week 12 | CNT | -2.7392 | 2.0748 | 128 | -1.32 | 0.1891 | 0.05 | -6.8444 | 1.3661 |
| Simple Effect Comparisons of AVISIT*TRT01P Least Squares Means By AVISIT | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Simple Effect Level | TRT01P | _TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| AVISIT Week 24 | TRT | CNT | -0.8166 | 2.2408 | 110.8 | -0.36 | 0.7162 | 0.05 | -5.2570 | 3.6238 |
| AVISIT Week 12 | TRT | CNT | -2.7392 | 2.0748 | 128 | -1.32 | 0.1891 | 0.05 | -6.8444 | 1.3661 |