| The SAS System |
| Model Information | |
|---|---|
| Data Set | WORK.DAT_TWISK_L |
| Response Variable | AVAL |
| Response Distribution | Gaussian |
| Link Function | Identity |
| Variance Function | Default |
| Variance Matrix Blocked By | USUBJID |
| Estimation Technique | Restricted Maximum Likelihood |
| Degrees of Freedom Method | Satterthwaite |
| Class Level Information | ||
|---|---|---|
| Class | Levels | Values |
| USUBJID | 152 | not printed |
| TRT01P | 2 | TRT CNT |
| Number of Observations Read | 456 |
|---|---|
| Number of Observations Used | 388 |
| Dimensions | |
|---|---|
| R-side Cov. Parameters | 6 |
| Columns in X | 7 |
| Columns in Z per Subject | 0 |
| Subjects (Blocks in V) | 152 |
| Max Obs per Subject | 3 |
| Optimization Information | |
|---|---|
| Optimization Technique | Dual Quasi-Newton |
| Parameters in Optimization | 6 |
| Lower Boundaries | 3 |
| Upper Boundaries | 0 |
| Fixed Effects | Profiled |
| Starting From | Data |
| Iteration History | |||||
|---|---|---|---|---|---|
| Iteration | Restarts | Evaluations | Objective Function |
Change | Max Gradient |
| 0 | 0 | 4 | 2993.790822 | . | 0.07201 |
| 1 | 0 | 4 | 2993.6264167 | 0.16440530 | 0.023002 |
| 2 | 0 | 2 | 2993.6150691 | 0.01134757 | 0.024202 |
| 3 | 0 | 2 | 2993.5960416 | 0.01902752 | 0.009295 |
| 4 | 0 | 2 | 2993.5891553 | 0.00688629 | 0.002943 |
| 5 | 0 | 4 | 2993.5871988 | 0.00195652 | 0.00603 |
| 6 | 0 | 2 | 2993.5861106 | 0.00108820 | 0.006998 |
| 7 | 0 | 4 | 2993.5818986 | 0.00421202 | 0.002652 |
| 8 | 0 | 3 | 2993.5810532 | 0.00084540 | 0.000874 |
| 9 | 0 | 3 | 2993.5808423 | 0.00021093 | 0.000299 |
| 10 | 0 | 3 | 2993.580839 | 0.00000326 | 0.000013 |
| Convergence criterion (GCONV=1E-8) satisfied. |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 2993.58 |
| AIC (smaller is better) | 3005.58 |
| AICC (smaller is better) | 3005.80 |
| BIC (smaller is better) | 3023.72 |
| CAIC (smaller is better) | 3029.72 |
| HQIC (smaller is better) | 3012.95 |
| Generalized Chi-Square | 383.00 |
| Gener. Chi-Square / DF | 1.00 |
| Covariance Parameter Estimates | |||
|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error |
| UN(1,1) | USUBJID | 236.49 | 28.4704 |
| UN(2,1) | USUBJID | 154.82 | 23.5844 |
| UN(2,2) | USUBJID | 213.21 | 26.5026 |
| UN(3,1) | USUBJID | 132.51 | 22.1948 |
| UN(3,2) | USUBJID | 133.17 | 21.4453 |
| UN(3,3) | USUBJID | 184.01 | 23.8996 |
| Solutions for Fixed Effects | ||||||
|---|---|---|---|---|---|---|
| Effect | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| |
| Intercept | 128.65 | 1.3044 | 138 | 98.63 | <.0001 | |
| Week_12 | 0.06757 | 1.3684 | 142.2 | 0.05 | 0.9607 | |
| Week_24 | -2.6422 | 1.4576 | 130.4 | -1.81 | 0.0722 | |
| Week_12*TRT01P | TRT | -4.3793 | 1.8561 | 128 | -2.36 | 0.0198 |
| Week_12*TRT01P | CNT | 0 | . | . | . | . |
| Week_24*TRT01P | TRT | -2.9029 | 1.9067 | 114.3 | -1.52 | 0.1307 |
| Week_24*TRT01P | CNT | 0 | . | . | . | . |
| Type III Tests of Fixed Effects | ||||
|---|---|---|---|---|
| Effect | Num DF | Den DF | F Value | Pr > F |
| Week_12 | 1 | 130.6 | 4.23 | 0.0417 |
| Week_24 | 1 | 115.1 | 13.54 | 0.0004 |
| Week_12*TRT01P | 1 | 128 | 5.57 | 0.0198 |
| Week_24*TRT01P | 1 | 114.3 | 2.32 | 0.1307 |