| The SAS System |
| Model Information | |
|---|---|
| Data Set | WORK.DAT_TWISK_L |
| Response Variable | AVAL |
| Response Distribution | Gaussian |
| Link Function | Identity |
| Variance Function | Default |
| Variance Matrix Blocked By | USUBJID |
| Estimation Technique | Restricted Maximum Likelihood |
| Degrees of Freedom Method | Satterthwaite |
| Class Level Information | ||
|---|---|---|
| Class | Levels | Values |
| USUBJID | 152 | not printed |
| AVISIT | 3 | Week 12 Week 24 Week 0 |
| TRT01P | 2 | TRT CNT |
| Number of Observations Read | 456 |
|---|---|
| Number of Observations Used | 388 |
| Dimensions | |
|---|---|
| R-side Cov. Parameters | 6 |
| Columns in X | 12 |
| Columns in Z per Subject | 0 |
| Subjects (Blocks in V) | 152 |
| Max Obs per Subject | 3 |
| Optimization Information | |
|---|---|
| Optimization Technique | Dual Quasi-Newton |
| Parameters in Optimization | 6 |
| Lower Boundaries | 3 |
| Upper Boundaries | 0 |
| Fixed Effects | Profiled |
| Starting From | Data |
| Iteration History | |||||
|---|---|---|---|---|---|
| Iteration | Restarts | Evaluations | Objective Function |
Change | Max Gradient |
| 0 | 0 | 4 | 2987.4425964 | . | 0.061223 |
| 1 | 0 | 4 | 2987.3255783 | 0.11701816 | 0.015814 |
| 2 | 0 | 2 | 2987.3195058 | 0.00607244 | 0.022925 |
| 3 | 0 | 4 | 2987.2966559 | 0.02284994 | 0.004953 |
| 4 | 0 | 2 | 2987.2953746 | 0.00128129 | 0.006575 |
| 5 | 0 | 2 | 2987.2935606 | 0.00181400 | 0.002471 |
| 6 | 0 | 3 | 2987.2926562 | 0.00090440 | 0.004739 |
| 7 | 0 | 2 | 2987.2912056 | 0.00145060 | 0.001116 |
| 8 | 0 | 3 | 2987.2909052 | 0.00030036 | 0.000884 |
| 9 | 0 | 3 | 2987.2908009 | 0.00010436 | 0.000083 |
| 10 | 0 | 3 | 2987.2908006 | 0.00000025 | 2.695E-6 |
| Convergence criterion (GCONV=1E-8) satisfied. |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 2987.29 |
| AIC (smaller is better) | 2999.29 |
| AICC (smaller is better) | 2999.51 |
| BIC (smaller is better) | 3017.43 |
| CAIC (smaller is better) | 3023.43 |
| HQIC (smaller is better) | 3006.66 |
| Generalized Chi-Square | 382.00 |
| Gener. Chi-Square / DF | 1.00 |
| Covariance Parameter Estimates | |||
|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error |
| UN(1,1) | USUBJID | 233.86 | 28.2557 |
| UN(2,1) | USUBJID | 153.09 | 23.3747 |
| UN(2,2) | USUBJID | 212.08 | 26.3100 |
| UN(3,1) | USUBJID | 131.04 | 21.9889 |
| UN(3,2) | USUBJID | 132.20 | 21.2916 |
| UN(3,3) | USUBJID | 183.18 | 23.7410 |
| Solutions for Fixed Effects | |||||||
|---|---|---|---|---|---|---|---|
| Effect | AVISIT | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| |
| Intercept | 130.68 | 1.8149 | 137 | 72.00 | <.0001 | ||
| TRT01P | TRT | -4.1466 | 2.5948 | 137 | -1.60 | 0.1123 | |
| TRT01P | CNT | 0 | . | . | . | . | |
| AVISIT | Week 12 | -0.6330 | 1.4361 | 130.6 | -0.44 | 0.6601 | |
| AVISIT | Week 24 | -3.5341 | 1.5596 | 116.3 | -2.27 | 0.0253 | |
| AVISIT | Week 0 | 0 | . | . | . | . | |
| AVISIT*TRT01P | Week 12 | TRT | -2.9472 | 2.0611 | 131 | -1.43 | 0.1551 |
| AVISIT*TRT01P | Week 12 | CNT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 24 | TRT | -1.0797 | 2.2219 | 115.4 | -0.49 | 0.6279 |
| AVISIT*TRT01P | Week 24 | CNT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 0 | TRT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 0 | CNT | 0 | . | . | . | . |
| Type III Tests of Fixed Effects | ||||
|---|---|---|---|---|
| Effect | Num DF | Den DF | F Value | Pr > F |
| TRT01P | 1 | 135.8 | 6.31 | 0.0132 |
| AVISIT | 2 | 117 | 6.73 | 0.0017 |
| AVISIT*TRT01P | 2 | 117 | 1.08 | 0.3439 |
| AVISIT*TRT01P Least Squares Means | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| AVISIT | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Week 12 | TRT | 122.95 | 1.8026 | 134.8 | 68.21 | <.0001 | 0.05 | 119.38 | 126.51 |
| Week 12 | CNT | 130.04 | 1.7553 | 133.6 | 74.09 | <.0001 | 0.05 | 126.57 | 133.51 |
| Week 24 | TRT | 121.92 | 1.7086 | 127 | 71.35 | <.0001 | 0.05 | 118.53 | 125.30 |
| Week 24 | CNT | 127.14 | 1.6822 | 128.6 | 75.58 | <.0001 | 0.05 | 123.81 | 130.47 |
| Week 0 | TRT | 126.53 | 1.8545 | 137 | 68.23 | <.0001 | 0.05 | 122.86 | 130.20 |
| Week 0 | CNT | 130.68 | 1.8149 | 137 | 72.00 | <.0001 | 0.05 | 127.09 | 134.26 |
| Differences of AVISIT*TRT01P Least Squares Means | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AVISIT | TRT01P | _AVISIT | _TRT01P | Estimate | Standard Error | DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Week 12 | TRT | Week 12 | CNT | -7.0939 | 2.5160 | 134.2 | -2.82 | 0.0055 | 0.05 | -12.0701 | -2.1177 |
| Week 12 | TRT | Week 24 | TRT | 1.0336 | 1.4738 | 114.6 | 0.70 | 0.4845 | 0.05 | -1.8858 | 3.9531 |
| Week 12 | TRT | Week 24 | CNT | -4.1927 | 2.4656 | 188 | -1.70 | 0.0907 | 0.05 | -9.0566 | 0.6711 |
| Week 12 | TRT | Week 0 | TRT | -3.5802 | 1.4784 | 131.3 | -2.42 | 0.0168 | 0.05 | -6.5048 | -0.6557 |
| Week 12 | TRT | Week 0 | CNT | -7.7269 | 2.5580 | 187.4 | -3.02 | 0.0029 | 0.05 | -12.7730 | -2.6808 |
| Week 12 | CNT | Week 24 | TRT | 8.1275 | 2.4496 | 185.5 | 3.32 | 0.0011 | 0.05 | 3.2949 | 12.9601 |
| Week 12 | CNT | Week 24 | CNT | 2.9011 | 1.4522 | 116.7 | 2.00 | 0.0481 | 0.05 | 0.02501 | 5.7773 |
| Week 12 | CNT | Week 0 | TRT | 3.5136 | 2.5535 | 186.3 | 1.38 | 0.1705 | 0.05 | -1.5238 | 8.5511 |
| Week 12 | CNT | Week 0 | CNT | -0.6330 | 1.4361 | 130.6 | -0.44 | 0.6601 | 0.05 | -3.4740 | 2.2080 |
| Week 24 | TRT | Week 24 | CNT | -5.2264 | 2.3978 | 127.8 | -2.18 | 0.0311 | 0.05 | -9.9708 | -0.4819 |
| Week 24 | TRT | Week 0 | TRT | -4.6139 | 1.5825 | 114.6 | -2.92 | 0.0043 | 0.05 | -7.7487 | -1.4791 |
| Week 24 | TRT | Week 0 | CNT | -8.7605 | 2.4926 | 194.8 | -3.51 | 0.0005 | 0.05 | -13.6765 | -3.8445 |
| Week 24 | CNT | Week 0 | TRT | 0.6125 | 2.5038 | 196 | 0.24 | 0.8070 | 0.05 | -4.3253 | 5.5503 |
| Week 24 | CNT | Week 0 | CNT | -3.5341 | 1.5596 | 116.3 | -2.27 | 0.0253 | 0.05 | -6.6231 | -0.4452 |
| Week 0 | TRT | Week 0 | CNT | -4.1466 | 2.5948 | 137 | -1.60 | 0.1123 | 0.05 | -9.2776 | 0.9843 |
| Simple Effect Comparisons of AVISIT*TRT01P Least Squares Means By AVISIT | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Simple Effect Level | TRT01P | _TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| AVISIT Week 12 | TRT | CNT | -7.0939 | 2.5160 | 134.2 | -2.82 | 0.0055 | 0.05 | -12.0701 | -2.1177 |
| AVISIT Week 24 | TRT | CNT | -5.2264 | 2.3978 | 127.8 | -2.18 | 0.0311 | 0.05 | -9.9708 | -0.4819 |
| AVISIT Week 0 | TRT | CNT | -4.1466 | 2.5948 | 137 | -1.60 | 0.1123 | 0.05 | -9.2776 | 0.9843 |