| The SAS System |
| Model Information | |
|---|---|
| Data Set | WORK.DAT_TWISK_L |
| Response Variable | AVAL |
| Response Distribution | Gaussian |
| Link Function | Identity |
| Variance Function | Default |
| Variance Matrix Blocked By | USUBJID |
| Estimation Technique | Restricted Maximum Likelihood |
| Degrees of Freedom Method | Satterthwaite |
| Class Level Information | ||
|---|---|---|
| Class | Levels | Values |
| USUBJID | 152 | not printed |
| AVISIT | 3 | Week 12 Week 24 Week 0 |
| ABLFL | 2 | Y N |
| TRT01P | 2 | TRT CNT |
| Number of Observations Read | 456 |
|---|---|
| Number of Observations Used | 388 |
| Dimensions | |
|---|---|
| R-side Cov. Parameters | 6 |
| Columns in X | 9 |
| Columns in Z per Subject | 0 |
| Subjects (Blocks in V) | 152 |
| Max Obs per Subject | 3 |
| Optimization Information | |
|---|---|
| Optimization Technique | Dual Quasi-Newton |
| Parameters in Optimization | 6 |
| Lower Boundaries | 3 |
| Upper Boundaries | 0 |
| Fixed Effects | Profiled |
| Starting From | Data |
| Iteration History | |||||
|---|---|---|---|---|---|
| Iteration | Restarts | Evaluations | Objective Function |
Change | Max Gradient |
| 0 | 0 | 4 | 2997.0773126 | . | 0.067493 |
| 1 | 0 | 4 | 2996.9517757 | 0.12553694 | 0.015671 |
| 2 | 0 | 2 | 2996.944912 | 0.00686364 | 0.021804 |
| 3 | 0 | 4 | 2996.9263444 | 0.01856760 | 0.005397 |
| 4 | 0 | 2 | 2996.9238906 | 0.00245383 | 0.00318 |
| 5 | 0 | 2 | 2996.9234905 | 0.00040011 | 0.004639 |
| 6 | 0 | 4 | 2996.9223977 | 0.00109276 | 0.002143 |
| 7 | 0 | 2 | 2996.9205342 | 0.00186348 | 0.000823 |
| 8 | 0 | 3 | 2996.9201344 | 0.00039989 | 0.000595 |
| 9 | 0 | 3 | 2996.9200545 | 0.00007982 | 0.000159 |
| 10 | 0 | 3 | 2996.9200533 | 0.00000126 | 6.256E-6 |
| Convergence criterion (GCONV=1E-8) satisfied. |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 2996.92 |
| AIC (smaller is better) | 3008.92 |
| AICC (smaller is better) | 3009.14 |
| BIC (smaller is better) | 3027.06 |
| CAIC (smaller is better) | 3033.06 |
| HQIC (smaller is better) | 3016.29 |
| Generalized Chi-Square | 384.00 |
| Gener. Chi-Square / DF | 1.00 |
| Covariance Parameter Estimates | |||
|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error |
| UN(1,1) | USUBJID | 233.91 | 28.2679 |
| UN(2,1) | USUBJID | 153.18 | 23.4459 |
| UN(2,2) | USUBJID | 212.73 | 26.4548 |
| UN(3,1) | USUBJID | 131.68 | 22.0681 |
| UN(3,2) | USUBJID | 130.97 | 21.2591 |
| UN(3,3) | USUBJID | 183.75 | 23.8790 |
| Solutions for Fixed Effects | |||||||
|---|---|---|---|---|---|---|---|
| Effect | ABLFL | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| |
| Intercept | 128.43 | 1.5545 | 133.2 | 82.62 | <.0001 | ||
| TRT01P | TRT | -6.0720 | 2.2227 | 132.7 | -2.73 | 0.0072 | |
| TRT01P | CNT | 0 | . | . | . | . | |
| ABLFL | Y | 1.8412 | 1.3007 | 124.1 | 1.42 | 0.1594 | |
| ABLFL | N | 0 | . | . | . | . | |
| ABLFL*TRT01P | Y | TRT | 2.1836 | 1.8624 | 123.5 | 1.17 | 0.2433 |
| ABLFL*TRT01P | Y | CNT | 0 | . | . | . | . |
| ABLFL*TRT01P | N | TRT | 0 | . | . | . | . |
| ABLFL*TRT01P | N | CNT | 0 | . | . | . | . |
| Type III Tests of Fixed Effects | ||||
|---|---|---|---|---|
| Effect | Num DF | Den DF | F Value | Pr > F |
| TRT01P | 1 | 135.7 | 5.03 | 0.0265 |
| ABLFL | 1 | 123.5 | 9.92 | 0.0021 |
| ABLFL*TRT01P | 1 | 123.5 | 1.37 | 0.2433 |
| ABLFL*TRT01P Least Squares Means | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ABLFL | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Y | TRT | 126.38 | 1.8426 | 136.7 | 68.59 | <.0001 | 0.05 | 122.74 | 130.03 |
| Y | CNT | 130.27 | 1.8034 | 136.8 | 72.24 | <.0001 | 0.05 | 126.71 | 133.84 |
| N | TRT | 122.36 | 1.5887 | 132.3 | 77.02 | <.0001 | 0.05 | 119.22 | 125.50 |
| N | CNT | 128.43 | 1.5545 | 133.2 | 82.62 | <.0001 | 0.05 | 125.36 | 131.51 |
| Differences of ABLFL*TRT01P Least Squares Means | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ABLFL | TRT01P | _ABLFL | _TRT01P | Estimate | Standard Error | DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Y | TRT | Y | CNT | -3.8884 | 2.5782 | 136.7 | -1.51 | 0.1338 | 0.05 | -8.9867 | 1.2100 |
| Y | TRT | N | TRT | 4.0248 | 1.3330 | 123 | 3.02 | 0.0031 | 0.05 | 1.3862 | 6.6634 |
| Y | TRT | N | CNT | -2.0472 | 2.4107 | 179.3 | -0.85 | 0.3969 | 0.05 | -6.8042 | 2.7099 |
| Y | CNT | N | TRT | 7.9132 | 2.4034 | 179.7 | 3.29 | 0.0012 | 0.05 | 3.1707 | 12.6556 |
| Y | CNT | N | CNT | 1.8412 | 1.3007 | 124.1 | 1.42 | 0.1594 | 0.05 | -0.7332 | 4.4156 |
| N | TRT | N | CNT | -6.0720 | 2.2227 | 132.7 | -2.73 | 0.0072 | 0.05 | -10.4685 | -1.6754 |
| Simple Effect Comparisons of ABLFL*TRT01P Least Squares Means By ABLFL | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Simple Effect Level |
TRT01P | _TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| ABLFL Y | TRT | CNT | -3.8884 | 2.5782 | 136.7 | -1.51 | 0.1338 | 0.05 | -8.9867 | 1.2100 |
| ABLFL N | TRT | CNT | -6.0720 | 2.2227 | 132.7 | -2.73 | 0.0072 | 0.05 | -10.4685 | -1.6754 |