| The SAS System |
| Model Information | |
|---|---|
| Data Set | WORK.DAT_TWISK_L |
| Response Variable | AVAL |
| Response Distribution | Gaussian |
| Link Function | Identity |
| Variance Function | Default |
| Variance Matrix Blocked By | USUBJID |
| Estimation Technique | Restricted Maximum Likelihood |
| Degrees of Freedom Method | Satterthwaite |
| Class Level Information | ||
|---|---|---|
| Class | Levels | Values |
| USUBJID | 139 | not printed |
| AVISIT | 2 | Week 24 Week 12 |
| TRT01P | 2 | TRT CNT |
| Number of Observations Read | 304 |
|---|---|
| Number of Observations Used | 249 |
| Dimensions | |
|---|---|
| R-side Cov. Parameters | 3 |
| Columns in X | 10 |
| Columns in Z per Subject | 0 |
| Subjects (Blocks in V) | 139 |
| Max Obs per Subject | 2 |
| Optimization Information | |
|---|---|
| Optimization Technique | Dual Quasi-Newton |
| Parameters in Optimization | 3 |
| Lower Boundaries | 2 |
| Upper Boundaries | 0 |
| Fixed Effects | Profiled |
| Starting From | Data |
| Iteration History | |||||
|---|---|---|---|---|---|
| Iteration | Restarts | Evaluations | Objective Function |
Change | Max Gradient |
| 0 | 0 | 4 | 1849.0363836 | . | 0.145027 |
| 1 | 0 | 4 | 1848.6426531 | 0.39373045 | 0.034812 |
| 2 | 0 | 4 | 1848.5969845 | 0.04566865 | 0.026056 |
| 3 | 0 | 2 | 1848.5792417 | 0.01774272 | 0.010147 |
| 4 | 0 | 2 | 1848.5754782 | 0.00376359 | 0.003077 |
| 5 | 0 | 4 | 1848.5750289 | 0.00044929 | 0.001009 |
| 6 | 0 | 3 | 1848.5749743 | 0.00005457 | 0.000023 |
| 7 | 0 | 3 | 1848.5749743 | 0.00000002 | 3.821E-7 |
| Convergence criterion (GCONV=1E-8) satisfied. |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 1848.57 |
| AIC (smaller is better) | 1854.57 |
| AICC (smaller is better) | 1854.67 |
| BIC (smaller is better) | 1863.38 |
| CAIC (smaller is better) | 1866.38 |
| HQIC (smaller is better) | 1858.15 |
| Generalized Chi-Square | 244.00 |
| Gener. Chi-Square / DF | 1.00 |
| Covariance Parameter Estimates | |||
|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error |
| UN(1,1) | USUBJID | 112.92 | 14.1832 |
| UN(2,1) | USUBJID | 45.4508 | 11.7012 |
| UN(2,2) | USUBJID | 110.02 | 14.7561 |
| Solutions for Fixed Effects | |||||||
|---|---|---|---|---|---|---|---|
| Effect | AVISIT | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| |
| Intercept | 50.0285 | 6.9767 | 124.7 | 7.17 | <.0001 | ||
| TRT01P | TRT | -4.5803 | 1.8814 | 128 | -2.43 | 0.0163 | |
| TRT01P | CNT | 0 | . | . | . | . | |
| BASE | 0.6123 | 0.05245 | 122.2 | 11.68 | <.0001 | ||
| AVISIT | Week 24 | -2.8715 | 1.4597 | 115.4 | -1.97 | 0.0516 | |
| AVISIT | Week 12 | 0 | . | . | . | . | |
| AVISIT*TRT01P | Week 24 | TRT | 1.9000 | 2.0797 | 114.3 | 0.91 | 0.3629 |
| AVISIT*TRT01P | Week 24 | CNT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 12 | TRT | 0 | . | . | . | . |
| AVISIT*TRT01P | Week 12 | CNT | 0 | . | . | . | . |
| Type III Tests of Fixed Effects | ||||
|---|---|---|---|---|
| Effect | Num DF | Den DF | F Value | Pr > F |
| TRT01P | 1 | 117.1 | 5.19 | 0.0246 |
| BASE | 1 | 122.2 | 136.31 | <.0001 |
| AVISIT | 1 | 114.3 | 3.41 | 0.0672 |
| AVISIT*TRT01P | 1 | 114.3 | 0.83 | 0.3629 |
| AVISIT*TRT01P Least Squares Means | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| AVISIT | TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Week 24 | TRT | 123.02 | 1.3640 | 114.2 | 90.19 | <.0001 | 0.05 | 120.32 | 125.72 |
| Week 24 | CNT | 125.70 | 1.3474 | 115.4 | 93.29 | <.0001 | 0.05 | 123.03 | 128.37 |
| Week 12 | TRT | 123.99 | 1.3443 | 127.3 | 92.23 | <.0001 | 0.05 | 121.33 | 126.65 |
| Week 12 | CNT | 128.57 | 1.3044 | 127.4 | 98.56 | <.0001 | 0.05 | 125.99 | 131.15 |
| Differences of AVISIT*TRT01P Least Squares Means | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AVISIT | TRT01P | _AVISIT | _TRT01P | Estimate | Standard Error | DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| Week 24 | TRT | Week 24 | CNT | -2.6803 | 1.9248 | 115.3 | -1.39 | 0.1664 | 0.05 | -6.4928 | 1.1322 |
| Week 24 | TRT | Week 12 | TRT | -0.9715 | 1.4814 | 113.2 | -0.66 | 0.5133 | 0.05 | -3.9064 | 1.9633 |
| Week 24 | TRT | Week 12 | CNT | -5.5518 | 1.8957 | 206.3 | -2.93 | 0.0038 | 0.05 | -9.2892 | -1.8144 |
| Week 24 | CNT | Week 12 | TRT | 1.7088 | 1.9107 | 209.4 | 0.89 | 0.3722 | 0.05 | -2.0580 | 5.4755 |
| Week 24 | CNT | Week 12 | CNT | -2.8715 | 1.4597 | 115.4 | -1.97 | 0.0516 | 0.05 | -5.7627 | 0.01965 |
| Week 12 | TRT | Week 12 | CNT | -4.5803 | 1.8814 | 128 | -2.43 | 0.0163 | 0.05 | -8.3030 | -0.8576 |
| Simple Effect Comparisons of AVISIT*TRT01P Least Squares Means By AVISIT | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Simple Effect Level | TRT01P | _TRT01P | Estimate | Standard Error |
DF | t Value | Pr > |t| | Alpha | Lower | Upper |
| AVISIT Week 24 | TRT | CNT | -2.6803 | 1.9248 | 115.3 | -1.39 | 0.1664 | 0.05 | -6.4928 | 1.1322 |
| AVISIT Week 12 | TRT | CNT | -4.5803 | 1.8814 | 128 | -2.43 | 0.0163 | 0.05 | -8.3030 | -0.8576 |